AL Amyloidosis

AL Amyloidosis
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AL amyloidosis and you

AL amyloidosis is one of the most common types of amyloidosis, where mutated white plasma cells in your bone marrow produce misfolded proteins creating deposits that affect organs such as the heart, kidneys, nerves, or parts of the digestive system. AL amyloidosis is not cancerous, although it may occasionally be associated with a rare type of blood cancer that also starts in white plasma cells called multiple myeloma.

Key topics

About AL Amyloidosis

Though AL amyloidosis is the most common form of amyloidosis, there are several types of the condition.

Symptoms

Symptoms for AL amyloidosis may be present before diagnosis. They range from fatigue and weakness to more serious problems that can impact organs such as the heart and kidneys.

Treatments

While there is no cure for AL amyloidosis, there are treatment options to help manage the condition.

Living with AL Amyloidosis

Get some tips on how to manage your day-to-day life with AL amyloidosis. Take care of your physical and emotional wellbeing.

Your Healthcare Team
You will meet many people during your care pathway. Understand the role each person will play in your treatment. This will vary from country to country.
Support and Caregivers

Although AL amyloidosis is rare, remember you are not alone. Gain access to support groups that can provide valuable insights into understanding a diagnosis.

References

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International Myeloma Foundation. Concise review of the disease and treatment options. 2017 edition. Available at: https://imf-d8-prod.s3.us-west-1.wasabisys.com/resource/ConciseReview.pdf Last accessed: February 2025.
Memorial Sloan Kettering Cancer Center. Multiple Myeloma Symptoms. https://www.mskcc.org/cancer-care/types/multiple-myeloma/multiple-myeloma-symptoms Last accessed: February 2025.
Gavriatopoulou M, et al. Metabolic Disorders in Multiple Myeloma. Int J Mol Sci. 2021;22(21):11430.
American Cancer Society. Multiple myeloma: causes, risk factors, and prevention. Available at: https://www.cancer.org/content/dam/CRC/PDF/Public/8739.00.pdf. Last accessed: February 2025.
Myeloma Patients Europe. Multiple Myeloma – A Patients’ Guide. Available at: www.mpeurope.org/files/Patients-guide-mpe-web-version-V2.pdf. Last accessed: February 2025.
International Myeloma Foundation. Understanding MGUS and Smoldering Multiple Myeloma, and Active Myeloma. Available at: https://www.myeloma.org/what-are-mgus-smm-mm Last accessed: February 2025.
International Myeloma Foundation. Concise review of the disease and treatment options. 2017 edition. Available at: https://imf-d8-prod.s3.us-west-1.wasabisys.com/resource/ConciseReview.pdf Last accessed: February 2025.
Moreau P, et al. Ann Oncol. 2017;28 (Suppl 4):iv52-iv61
WebMD. Smoldering Multiple Myeloma. Available at: https://www.webmd.com/cancer/multiple-myeloma/smoldering-multiple-myeloma. Last accessed: February 2025.
American Cancer Society. About multiple myeloma. Available at: https://www.cancer.org/cancer/types/multiple-myeloma/about/what-is-multiple-myeloma.html. Last accessed: February 2025.
Hughes, D, Yong, K, Ramasamy, K et al. Diagnosis and management of smouldering myeloma: A British Society for Haematology Good Practice Paper. British Journal of Haematology. 2024: 1193-2016.
NHS Inform. Multiple Myeloma – About multiple myeloma. Available at: https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/multiple-myeloma
Bahlis NJ, Lazarus HM. Multiple myeloma-associated AL amyloidosis. Bone Marrow Transplantation. 2006;38;7-15.
Vaxman I, Gatt ME. Smouldering multiple myeloma: To seek or not to seek? To treat or not to treat. That is the question. Br J Haematol. 2024; 204(4): 1141–1142.
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